IL-31 anticorps (AA 1-164)

N° du produit ABIN7868231

Cet anticorps Souris Monoclonal détecte spécifiquement IL-31 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IL-31 anticorps (AA 1-164) (ABIN7868231)

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-31 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL31-7333

Détail du produit anti-IL-31 anticorps

Épitope: AA 1-164

Fonction: Interleukin-31 Antibody / IL-31

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-164) from the human protein was used as the immunogen for the Interleukin-31 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Interleukin-31 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Interleukin-31 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IL-31

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Autre désignation: Interleukin-31

Sujet: IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

UniProt: Q6EBC2