MCEMP1 anticorps (AA 1-183)

N° du produit ABIN7868272

Cet anticorps anti-MCEMP1 Polyclonal Lapin (ABIN7868272) détecte spécifiquement MCEMP1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MCEMP1 anticorps (AA 1-183) (ABIN7868272)

Antigène: MCEMP1 (Mast Cell Expressed Membrane Protein 1 (MCEMP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCEMP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MCEMP1 anticorps

Épitope: AA 1-183

Fonction: MCEMP1 Antibody / Mast cell-expressed membrane protein 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MCEMP1 recombinant protein (Position: M1-Q183) was used as the immunogen for the MCEMP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MCEMP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MCEMP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MCEMP1

Antigène: MCEMP1 (Mast Cell Expressed Membrane Protein 1 (MCEMP1))

Autre désignation: MCEMP1

Sujet: MCEMP1 antibody detects Mast cell-expressed membrane protein 1, a type I transmembrane protein implicated in immune cell activation and inflammatory signaling. The UniProt recommended name is Mast cell-expressed membrane protein 1 (MCEMP1). This protein is predominantly expressed in mast cells, monocytes, and macrophages, where it may function as a receptor or co-stimulatory molecule regulating immune responses.

Functionally, MCEMP1 antibody identifies a 177-amino-acid membrane glycoprotein featuring a short extracellular region, a single transmembrane domain, and a cytoplasmic tail containing an immunoreceptor tyrosine-based activation motif (ITAM). Upon phosphorylation, MCEMP1 can recruit SYK kinase and other signaling molecules, promoting cytokine production and cell activation.

The MCEMP1 gene is located on chromosome 19q13.4 and is expressed primarily in immune cells of the myeloid lineage, including mast cells, basophils, and macrophages. MCEMP1 expression increases during inflammation, allergic responses, and infection, suggesting a role in innate immune activation. It may also contribute to cytokine cross-talk between immune cells and epithelial barriers.

Pathologically, aberrant MCEMP1 expression is associated with allergic inflammation, asthma, and sepsis. Its upregulation in immune cells correlates with hyperinflammatory states, making it a potential biomarker for inflammatory disorders. Research using MCEMP1 antibody helps clarify its role in immune activation and signaling mechanisms.

MCEMP1 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immune cell membrane proteins. NSJ Bioreagents provides MCEMP1 antibody reagents optimized for research in immunology, inflammation, and signal transduction.

Structurally, Mast cell-expressed membrane protein 1 contains a single-pass transmembrane segment and cytoplasmic ITAM motifs that drive downstream kinase signaling. This antibody aids in studies of MCEMP1's potential receptor functions and involvement in immune regulation.

UniProt: Q8IX19