VPRBP anticorps (AA 1-195)

N° du produit ABIN7868350

Cet anticorps anti-VPRBP Polyclonal Lapin (ABIN7868350) détecte spécifiquement VPRBP dans ELISA, WB, FACS, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour VPRBP anticorps (AA 1-195) (ABIN7868350)

Antigène: VPRBP (Vpr (HIV-1) Binding Protein (VPRBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPRBP est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-VPRBP anticorps

Épitope: AA 1-195

Fonction: VPRBP Antibody / DCAF1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-R195) was used as the immunogen for the VPRBP antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the VPRBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the VPRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur VPRBP

Antigène: VPRBP (Vpr (HIV-1) Binding Protein (VPRBP))

Autre désignation: VPRBP

Classe de substances: Viral Protein

Sujet: VprBP was first identified as a protein that can interact with HIV-1 viral protein R. It is a component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with HIV-1 virus Vpr protein and HIV-2 virus Vpx protein. VprBP is a 1,507-amino acid protein that contains conserved domains, including YXXY repeats, the Lis homology motif, and WD40 repeats. Through binding to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, which in turn leads to the induction of G2 phase arrest in the virus-infected cells. Recently it has been reported that VprBP is able to regulate the p53-induced transcription and apoptotic pathway.

UniProt: Q9Y4B6