ASCL1 anticorps (AA 1-196)

N° du produit ABIN7868352

L’anticorps anti-ASCL1 Polyclonal Lapin est utilisé pour la détection de ASCL1 dans des échantillons de Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour ASCL1 anticorps (AA 1-196) (ABIN7868352)

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASCL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ASCL1 anticorps

Épitope: AA 1-196

Fonction: Zebrafish Ascl1a Antibody / Achaete-scute homolog 1

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Ascl1a recombinant protein (amino acids M1-F196) was used as the immunogen for the Zebrafish Ascl1a antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Ascl1a antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Ascl1a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ASCL1

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Autre désignation: Ascl1a

Sujet: Achaete-scute family bHLH transcription factor 1a (Ascl1a) is a basic helix-loop-helix (bHLH) transcription factor that plays a crucial role in neurogenesis and cell fate determination. In zebrafish (Danio rerio), Ascl1a is a key regulator of neural progenitor proliferation and differentiation, particularly within the central nervous system, retina, and intestinal epithelium.

Ascl1a acts downstream of proneural signaling pathways and promotes the commitment of progenitor cells to a neuronal lineage. It is expressed in neural precursor cells during embryonic development and is reactivated in regenerative contexts. In the zebrafish retina and brain, Ascl1a is essential for the regeneration of neurons following injury, making it a prominent factor in regenerative neurobiology.

Zebrafish Ascl1a is widely used as a model for studying the molecular mechanisms of neuronal differentiation, stem cell biology, and tissue regeneration. Its expression is tightly regulated by signaling pathways such as Notch, and its function is conserved across vertebrates, including in mammalian neurogenesis.

UniProt: Q90259

Pathways: Dopaminergic Neurogenesis