FAP anticorps (AA 1-200)

N° du produit ABIN7868481

L’anticorps anti-FAP Monoclonal Souris est utilisé pour la détection de FAP dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour FAP anticorps (AA 1-200) (ABIN7868481)

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FAP-4854

Détail du produit anti-FAP anticorps

Épitope: AA 1-200

Fonction: FAP Antibody / Fibroblast Activation Protein Alpha

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-200 was used as the immunogen for the FAP antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the FAP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the FAP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur FAP

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Autre désignation: FAP

Sujet: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

UniProt: Q12884

Pathways: Tube Formation