FAP anticorps (AA 1-200)

N° du produit ABIN7868483

Cet anticorps Souris Monoclonal détecte spécifiquement FAP dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FAP anticorps (AA 1-200) (ABIN7868483)

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FAP-4853

Détail du produit anti-FAP anticorps

Épitope: AA 1-200

Fonction: Fibroblast Activation Protein Alpha Antibody / FAP

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-200 was used as the immunogen for the Fibroblast Activation Protein Alpha antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the Fibroblast Activation Protein Alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Fibroblast Activation Protein Alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur FAP

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Autre désignation: Fibroblast Activation Protein Alpha

Sujet: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

UniProt: Q12884

Pathways: Tube Formation