Neurogenin 3 anticorps (AA 1-200)

N° du produit ABIN7868677

Cet anticorps anti-Neurogenin 3 Monoclonal Souris (Clone NGN3-1808) (ABIN7868677) détecte spécifiquement Neurogenin 3 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Neurogenin 3 anticorps (AA 1-200) (ABIN7868677)

Antigène: Neurogenin 3 (NEUROG3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Neurogenin 3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NGN3-1808

Détail du produit anti-Neurogenin 3 anticorps

Épitope: AA 1-200

Fonction: Neurogenin 3 Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein (within amino acids 1-200) from the human protein was used as the immunogen for the Neurogenin 3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Neurogenin 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Neurogenin 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Neurogenin 3

Antigène: Neurogenin 3 (NEUROG3)

Autre désignation: Neurogenin 3

Sujet: This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.

UniProt: Q9Y4Z2