NeuN anticorps (AA 1-200)

N° du produit ABIN7868726

Cet anticorps Souris Monoclonal détecte spécifiquement NeuN dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour NeuN anticorps (AA 1-200) (ABIN7868726)

Antigène: NeuN (RBFOX3) (RNA Binding Protein, Fox-1 Homolog 3 (RBFOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NeuN est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: NEUN-7167

Détail du produit anti-NeuN anticorps

Épitope: AA 1-200

Fonction: RBFOX3 Antibody / NeuN / Fox3 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the RBFOX3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the RBFOX3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the RBFOX3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur NeuN

Antigène: NeuN (RBFOX3) (RNA Binding Protein, Fox-1 Homolog 3 (RBFOX3))

Autre désignation: RBFOX3

Sujet: This antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN/Rbfox3, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuro. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function, however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.

UniProt: A6NFN3