SPARC anticorps (AA 1-200)

N° du produit ABIN7868737

Cet anticorps anti-SPARC Monoclonal Souris (Clone OSTN-3304) (ABIN7868737) détecte spécifiquement SPARC dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SPARC anticorps (AA 1-200) (ABIN7868737)

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SPARC est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: OSTN-3304

Détail du produit anti-SPARC anticorps

Épitope: AA 1-200

Fonction: SPARC Antibody / Osteonectin

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-200 was used as the immunogen for the SPARC antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the SPARC antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SPARC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SPARC

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Autre désignation: SPARC

Sujet: SPARC (for secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. It is identical to osteonectin, a protein important to bone calcification that is highly conserved between species. SPARC, which can be selectively expressed by the endothelium in response to certain types of injury, induces rounding in adherent endothelial cells in vitro. It regulates endothelial barrier function through F-Actin-dependent changes in cell shape, coincident with the appearance of intercellular gaps, which provide a paracellular pathway for extravasation of macromolecules.

UniProt: P09486

Pathways: Autophagy