TREM2 anticorps (AA 1-200)

N° du produit ABIN7868779

Cet anticorps anti-TREM2 Monoclonal Souris (Clone TREM2-7210) (ABIN7868779) détecte spécifiquement TREM2 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TREM2 anticorps (AA 1-200) (ABIN7868779)

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TREM2-7210

Détail du produit anti-TREM2 anticorps

Épitope: AA 1-200

Fonction: TREM2 Antibody

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-200 was used as the immunogen for the TREM2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TREM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TREM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TREM2

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Autre désignation: TREM2

Sujet: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), known as Nasu-Hakola disease , is a recessively inherited disease where individuals display early-onset progressive dementia and bone cysts, which leads to death. Mutations in TYROBP (DAP12), which codes for a membrane receptor component in natural-killer and myeloid cells and mutations in triggering receptor expressed on myeloid cells-2 (TREM-2), correlate well to the pathology of PLOSL. TREM-2 is a cell surface receptor on human monocyte-derived dendritic cells that forms a receptor signaling complex with DAP12 and triggers activation of the immune response in macrophages and dendritic cells (DC). The TREM-2/DAP12 complex is a molecular promoter of upregulation of CC chemokine receptor 7, partial DC maturation, and DC survival through activation of protein tyrosine kinases and extracellular signal regulated kinase. The human chronic inflammatory TREM-2 gene maps to chromosome 6p21.1 and encodes a 230 amino acid protein.

UniProt: Q9NZC2