BCAP31 anticorps (AA 1-242)

N° du produit ABIN7868908

Cet anticorps anti-BCAP31 Polyclonal Lapin (ABIN7868908) détecte spécifiquement BCAP31 dans WB, ELISA, IHC, IF, IP, ICC et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BCAP31 anticorps (AA 1-242) (ABIN7868908)

Antigène: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAP31 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-BCAP31 anticorps

Épitope: AA 1-242

Fonction: BCAP31 Antibody / B-cell receptor-associated protein 31

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human BAP31/BCAP31 recombinant protein (Position: M1-D242) was used as the immunogen for the BCAP31 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the BCAP31 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the BCAP31 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur BCAP31

Antigène: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Autre désignation: BCAP31

Sujet: BCAP31 antibody detects B-cell receptor-associated protein 31, an integral endoplasmic reticulum (ER) membrane protein that functions as a chaperone and adaptor in protein trafficking and apoptosis regulation. BCAP31 is a member of the BCAP31 family, which includes BCAP29, and plays crucial roles in protein quality control, ER-Golgi transport, and caspase-mediated cell death. The BCAP31 antibody is used in cell biology and immunology research to study membrane trafficking, ER stress, and apoptotic signaling.

BCAP31 is encoded by the BCAP31 gene located on the X chromosome (Xp22.13). The protein is approximately 28 kilodaltons and contains three transmembrane domains with a cytoplasmic C-terminal tail that interacts with diverse partners, including BCL2 and procaspase-8. These interactions position BCAP31 at the intersection of the secretory and apoptotic pathways, integrating ER homeostasis with cell death regulation.

The BCAP31 antibody detects a 28 kilodalton band on western blot and shows reticular ER staining consistent with its localization. BCAP31 forms complexes with chaperones such as calnexin and Sec61, assisting in the folding and export of glycoproteins from the ER to the Golgi apparatus. It also mediates ER retention or degradation of misfolded proteins, linking it to the unfolded protein response (UPR).

In apoptosis, BCAP31 acts as a substrate for caspase cleavage, generating pro-apoptotic fragments that amplify death signaling through mitochondria. This dual role allows BCAP31 to serve as both a quality control checkpoint and a stress sensor. Mutations or deletions of BCAP31 cause X-linked intellectual disability syndromes characterized by developmental delay and hearing loss, emphasizing its importance in neuronal maintenance.

BCAP31 also contributes to immune cell signaling and antigen presentation by modulating trafficking of MHC class I molecules. NSJ Bioreagents provides a validated BCAP31 antibody optimized for western blot, immunofluorescence, and ER-Golgi transport analysis, supporting research into protein folding, apoptosis regulation, and membrane trafficking.

UniProt: P51572

Pathways: Positive Regulation of Endopeptidase Activity