HMMR anticorps (AA 1-250)

N° du produit ABIN7868943

L’anticorps anti-HMMR Monoclonal Souris est utilisé pour la détection de HMMR dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour HMMR anticorps (AA 1-250) (ABIN7868943)

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HMMR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: HMMR-8021

Détail du produit anti-HMMR anticorps

Épitope: AA 1-250

Fonction: CD168 Antibody / HMMR (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the CD168 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CD168 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the CD168 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur HMMR

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Autre désignation: CD168

Sujet: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process