RAD17 anticorps (AA 1-267)

N° du produit ABIN7869008

Cet anticorps Lapin Polyclonal détecte spécifiquement RAD17 dans WB, ELISA, FACS et IHC (p). Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour RAD17 anticorps (AA 1-267) (ABIN7869008)

Antigène: RAD17

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD17 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RAD17 anticorps

Épitope: AA 1-267

Fonction: Rad17 Antibody

Purification: Affinity purified

Immunogène: Recombinant mouse protein (amino acids M1-Q267) was used as the immunogen for the Rad17 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Rad17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Rad17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur RAD17

Antigène: RAD17

Autre désignation: Rad17

Sujet: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

UniProt: Q6NXW6