SESN1 anticorps (AA 1-275)

N° du produit ABIN7869032

Cet anticorps Lapin Polyclonal détecte spécifiquement SESN1 dans WB, ELISA, FACS et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SESN1 anticorps (AA 1-275) (ABIN7869032)

Antigène: SESN1 (Sestrin 1 (SESN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SESN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-SESN1 anticorps

Épitope: AA 1-275

Fonction: PA26 Antibody / SESN1 / SEST1 / Sestrin 1

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids M1-A275) was used as the immunogen for the PA26 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PA26 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PA26 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SESN1

Antigène: SESN1 (Sestrin 1 (SESN1))

Autre désignation: PA26

Sujet: Sestrin 1, also known as p53-regulated protein PA26 and SEST1, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt: Q9Y6P5