APOH anticorps (AA 1-300)

N° du produit ABIN7869117

L’anticorps anti-APOH Monoclonal Souris est utilisé pour la détection de APOH dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour APOH anticorps (AA 1-300) (ABIN7869117)

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOH est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: APOH-3682

Détail du produit anti-APOH anticorps

Épitope: AA 1-300

Fonction: Apolipoprotein H Antibody / APOH

Purification: Protein A/G affinity

Immunogène: A recombinant fragment (within amino acids 1-300) of human APOH protein was used as the immunogen for the Apolipoprotein H antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the Apolipoprotein H antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Apolipoprotein H antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur APOH

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Autre désignation: Apolipoprotein H

Sujet: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

UniProt: P02749