Syntaxin 16 anticorps (AA 1-301)

N° du produit ABIN7869165

L’anticorps anti-Syntaxin 16 Polyclonal Lapin est utilisé pour la détection de Syntaxin 16 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour Syntaxin 16 anticorps (AA 1-301) (ABIN7869165)

Antigène: Syntaxin 16 (STX16)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Syntaxin 16 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Syntaxin 16 anticorps

Épitope: AA 1-301

Fonction: STX16 Antibody / Syntaxin 16

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human Syntaxin 16/STX16 recombinant protein (Position: M1-K301) was used as the immunogen for the STX16 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STX16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Syntaxin 16

Antigène: Syntaxin 16 (STX16)

Autre désignation: STX16

Sujet: STX16 antibody detects Syntaxin 16, encoded by the STX16 gene. Syntaxin 16 is a member of the SNARE family of proteins that regulate vesicle trafficking, membrane fusion, and intracellular transport. STX16 antibody provides researchers with a specific reagent for studying Golgi and endosomal transport, protein sorting, and cellular homeostasis.

Syntaxin 16 is a membrane-anchored protein localized primarily to the Golgi apparatus and endosomal compartments. Research using STX16 antibody has shown that it forms SNARE complexes with vesicle associated membrane proteins and SNAP proteins, enabling membrane fusion during trafficking. This function is essential for recycling receptors, delivering enzymes, and maintaining compartment identity.

Studies with STX16 antibody have revealed that Syntaxin 16 is critical for retrograde transport from endosomes to the Golgi. By interacting with the retromer complex and cargo adaptors, it ensures retrieval of proteins such as the cation independent mannose-6-phosphate receptor. This pathway maintains lysosomal enzyme delivery and Golgi organization, demonstrating the importance of STX16 in vesicle logistics.

Dysfunction of Syntaxin 16 has been implicated in disease. Research using STX16 antibody has shown that chromosomal rearrangements near the STX16 gene contribute to pseudohypoparathyroidism type 1b, a metabolic disorder characterized by abnormal imprinting and hormone resistance. Altered expression of STX16 has also been observed in cancer and neurodegenerative conditions, linking vesicle transport to disease mechanisms.

Syntaxin 16 is further implicated in glucose metabolism. Studies with STX16 antibody have demonstrated that it participates in trafficking of glucose transporters, affecting insulin responsive glucose uptake. This places Syntaxin 16 within networks connecting vesicle trafficking with metabolic regulation, emphasizing its diverse cellular roles.

STX16 antibody is widely used in western blotting, immunofluorescence, and immunohistochemistry. Western blotting quantifies expression and isoform diversity, immunofluorescence demonstrates Golgi localization and co-localization with trafficking machinery, and immunohistochemistry reveals tissue-specific expression. These applications make STX16 antibody indispensable in vesicle transport research.

By supplying validated STX16 antibody reagents, NSJ Bioreagents supports studies into vesicle fusion, Golgi biology, and disease. Detection of Syntaxin 16 provides insights into how SNARE proteins regulate trafficking pathways and maintain homeostasis.

UniProt: O14662

Pathways: Synaptic Vesicle Exocytosis