TYMS anticorps (AA 1-313)

N° du produit ABIN7869182

Cet anticorps Lapin Polyclonal détecte spécifiquement TYMS dans WB, IF, ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain, Rat et Singe.

Aperçu rapide pour TYMS anticorps (AA 1-313) (ABIN7869182)

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Reactivité: Humain, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYMS est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TYMS anticorps

Épitope: AA 1-313

Fonction: TYMS Antibody / Thymidylate Synthase

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids M1-V313) was used as the immunogen for the TYMS antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TYMS antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TYMS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TYMS

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Autre désignation: TYMS

Sujet: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases