ETV4 anticorps (AA 1-333)

N° du produit ABIN7869205

Cet anticorps anti-ETV4 Polyclonal Lapin (ABIN7869205) détecte spécifiquement ETV4 dans WB. L’anticorps est réactif avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour ETV4 anticorps (AA 1-333) (ABIN7869205)

Antigène: ETV4 (Ets Variant 4 (ETV4))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETV4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ETV4 anticorps

Épitope: AA 1-333

Fonction: Zebrafish Etv4 Antibody / ETS translocation variant 4 / Pea3

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Etv4 recombinant protein (amino acids M1-E333) was used as the immunogen for the Zebrafish Etv4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Etv4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Etv4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ETV4

Antigène: ETV4 (Ets Variant 4 (ETV4))

Autre désignation: Etv4

Sujet: Ets variant 4 (Etv4), also known as Pea3, is a member of the ETS family of transcription factors characterized by a conserved ETS DNA-binding domain that recognizes purine-rich sequences in target gene promoters. In zebrafish (Danio rerio), etv4 plays an essential role in embryonic development, particularly in processes regulated by fibroblast growth factor (FGF) signaling.

Etv4 functions as a key downstream effector of FGF signaling pathways, mediating transcriptional responses critical for tissue patterning and organogenesis. During zebrafish embryogenesis, etv4 is expressed in a variety of dynamic domains including the posterior mesoderm, developing somites, neural crest, and the pronephros. It acts in concert with other Pea3 subfamily members such as Etv5 to regulate genes involved in cell migration, proliferation, and differentiation.

Zebrafish etv4 has been extensively studied in the context of limb and fin development, neuromast formation, and branchial arch morphogenesis, making it a useful molecular marker for FGF activity and mesenchymal-epithelial interactions. Disruption of etv4 expression or function impairs normal developmental processes, underscoring its regulatory importance.

Due to its conserved function and regulated expression, zebrafish Etv4 serves as a valuable model for studying ETS transcription factors in vertebrate development and disease pathways, including cancer metastasis and skeletal disorders.

UniProt: Q9PUQ1