PUM1 anticorps (AA 1-361)

N° du produit ABIN7869251

Cet anticorps Lapin Polyclonal détecte spécifiquement PUM1 dans WB, IF, ELISA, ICC et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PUM1 anticorps (AA 1-361) (ABIN7869251)

Antigène: PUM1 (Pumilio Homolog 1 (PUM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PUM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-PUM1 anticorps

Épitope: AA 1-361

Fonction: PUM1 Antibody / Pumilio 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PUM1 recombinant protein (Position: M1-D361) was used as the immunogen for the PUM1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PUM1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PUM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PUM1

Antigène: PUM1 (Pumilio Homolog 1 (PUM1))

Autre désignation: PUM1

Sujet: PUM1 antibody detects Pumilio homolog 1, encoded by the PUM1 gene. Pumilio homolog 1 is a highly conserved RNA binding protein that regulates post-transcriptional gene expression by controlling mRNA stability and translation. PUM1 antibody provides researchers with an essential reagent to study RNA biology, developmental regulation, and disease mechanisms involving RNA processing.

Pumilio homolog 1 belongs to the Pumilio and FBF family of proteins, which are characterized by their PUF RNA binding domains. Research using PUM1 antibody has shown that PUM1 binds to specific sequences in the 3' untranslated regions of target mRNAs, promoting degradation or translational repression. Through this activity, PUM1 regulates diverse biological processes, including cell proliferation, differentiation, and neuronal function.

Studies with PUM1 antibody have demonstrated that it participates in developmental pathways by regulating maternal mRNAs during embryogenesis. In germline cells, PUM1 contributes to stem cell maintenance by repressing differentiation-promoting transcripts. These findings underscore its importance in balancing self-renewal and differentiation in development.

Pumilio homolog 1 also influences neuronal biology. Research using PUM1 antibody has shown that it regulates synaptic function by controlling translation of synaptic mRNAs. Dysregulation of PUM1 is associated with neurological disorders, including intellectual disability and ataxia. Mutations that impair PUM1 function alter neuronal protein synthesis, contributing to disease pathology.

In cancer, PUM1 has been implicated in tumor progression. Studies with PUM1 antibody have revealed that altered expression modulates proliferation and survival pathways, supporting malignant growth. By controlling mRNA turnover of oncogenes and tumor suppressors, PUM1 integrates into signaling networks that determine tumor cell fate.

PUM1 antibody is widely used in western blotting, immunohistochemistry, and RNA immunoprecipitation. Western blotting quantifies protein expression, immunohistochemistry reveals localization in tissues such as brain and ovary, and RNA immunoprecipitation identifies bound target transcripts. These applications make PUM1 antibody indispensable for RNA biology research.

By providing validated PUM1 antibody reagents, NSJ Bioreagents supports studies into RNA regulation, development, and disease. Detection of Pumilio homolog 1 provides researchers with insight into how post-transcriptional control shapes cellular function.

UniProt: Q14671