SYT10 anticorps (AA 1-363)

N° du produit ABIN7869255

L’anticorps anti-SYT10 Polyclonal Lapin est utilisé pour la détection de SYT10 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC et IF.

Aperçu rapide pour SYT10 anticorps (AA 1-363) (ABIN7869255)

Antigène: SYT10 (Synaptotagmin X (SYT10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYT10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SYT10 anticorps

Épitope: AA 1-363

Fonction: SYT10 Antibody / Synaptotagmin 10

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human Synaptotagmin-10/SYT10 recombinant protein (Position: M1-D363) was used as the immunogen for the SYT10 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SYT10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SYT10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SYT10

Antigène: SYT10 (Synaptotagmin X (SYT10))

Autre désignation: SYT10

Sujet: SYT10 antibody detects Synaptotagmin-10, a member of the synaptotagmin family of membrane-trafficking proteins involved in calcium-dependent vesicle exocytosis. The UniProt recommended name is Synaptotagmin-10 (SYT10), with alternate names including Synaptotagmin X and p65. Synaptotagmins act as calcium sensors that regulate synaptic vesicle fusion with the plasma membrane, mediating neurotransmitter and hormone release. SYT10, like other synaptotagmins, contains two C2 domains that bind calcium and phospholipids to trigger vesicle exocytosis.

Functionally, SYT10 antibody identifies a 565-amino-acid protein that plays a role in the regulation of insulin secretion and neuronal exocytosis. SYT10 is unique among synaptotagmins because it is expressed in both neuronal and non-neuronal tissues, including the pancreas and pituitary gland. It is associated with the release of insulin-like growth factor 1 (IGF-1) and other neuropeptides in a calcium-dependent manner. Through its C2A and C2B domains, SYT10 mediates the calcium-triggered docking and fusion of secretory vesicles, ensuring precise timing of exocytosis following intracellular signaling events.

The SYT10 antibody is used to study secretory pathways, vesicular transport, and neuronal communication. In neurons, SYT10 localizes to presynaptic membranes and regulates neurotransmitter release by acting as a Ca2+-sensor for synaptic vesicle fusion. In endocrine cells, it supports hormone secretion by coupling calcium signaling to vesicular exocytosis. Expression of SYT10 is enriched in specific brain regions such as the cortex and cerebellum, reflecting specialized regulatory roles in neurotransmission.

Mutations or dysregulation of SYT10 have been associated with altered synaptic signaling and insulin secretion. The SYT10 gene is located on chromosome 12q21.32 and encodes a protein with two conserved C2 domains responsible for calcium and phospholipid binding. Unlike some synaptotagmins that promote rapid synchronous release, SYT10 is implicated in sustained and asynchronous release events. Research indicates that SYT10 may also participate in neurotrophic signaling and membrane repair processes.

SYT10 antibody applications include western blotting, immunocytochemistry, and confocal microscopy to examine vesicle trafficking, synaptic plasticity, and calcium-triggered secretion. Its use extends to neuroendocrine and pancreatic models where SYT10 mediates regulated exocytosis. NSJ Bioreagents provides this antibody validated for research applications in neuroscience, endocrinology, and cell signaling to investigate vesicular transport and exocytotic mechanisms.

UniProt: Q6XYQ8