IFI44 anticorps (AA 1-370)

N° du produit ABIN7869263

Cet anticorps Lapin Polyclonal détecte spécifiquement IFI44 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Souris et Rat.

Aperçu rapide pour IFI44 anticorps (AA 1-370) (ABIN7869263)

Antigène: IFI44 (Interferon-Induced Protein 44 (IFI44))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFI44 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-IFI44 anticorps

Épitope: AA 1-370

Fonction: IFI44 Antibody / Interferon induced protein 44

Purification: Immunogen affinity purified

Immunogène: E.coli-derived mouse IFI44 recombinant protein (Position: M1-H370) was used as the immunogen for the IFI44 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the IFI44 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the IFI44 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur IFI44

Antigène: IFI44 (Interferon-Induced Protein 44 (IFI44))

Autre désignation: IFI44

Sujet: IFI44 antibody detects Interferon-induced protein 44, encoded by the IFI44 gene on chromosome 1p31.1. IFI44 antibody is commonly used in immunology, antiviral, and autoimmune disease research. IFI44 is an interferon-stimulated gene product induced by type I interferons and viral infection. It contributes to the host antiviral defense response and is a biomarker of interferon pathway activation.

Structurally, IFI44 is a ~50 kDa protein with coiled-coil domains but lacks known catalytic motifs. It localizes predominantly to the cytoplasm, with potential mitochondrial and cytoskeletal associations. Its structure suggests a role as a scaffold or regulator rather than an enzyme.

Functionally, IFI44 is strongly induced by viral infections including influenza, hepatitis C virus, and SARS-CoV. It enhances innate immune responses, possibly by modulating cytoskeletal dynamics or mitochondrial function. Researchers use IFI44 antibody to study interferon responses, viral pathogenesis, and autoimmune disease mechanisms.

Clinically, IFI44 is elevated in autoimmune diseases such as systemic lupus erythematosus and dermatomyositis, where interferon signatures correlate with disease severity. It has been proposed as a diagnostic biomarker for interferon-driven conditions. IFI44 polymorphisms may also influence susceptibility to viral infections. NSJ Bioreagents provides IFI44 antibody to support immunology and infectious disease research.

Experimentally, IFI44 antibody is used in western blotting to detect the ~50 kDa protein, in immunohistochemistry to assess tissue expression, and in immunofluorescence to study cytoplasmic distribution. Transcriptomic studies often pair IFI44 expression with IFI44L to define interferon response signatures, and IFI44 antibody provides the protein-level validation.

UniProt: Q8BV66