PSTPIP1 anticorps (AA 1-394)

N° du produit ABIN7869296

Cet anticorps Lapin Polyclonal détecte spécifiquement PSTPIP1 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PSTPIP1 anticorps (AA 1-394) (ABIN7869296)

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSTPIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-PSTPIP1 anticorps

Épitope: AA 1-394

Fonction: PSTPIP1 Antibody / PEST phosphatase-interacting protein 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PSTPIP1 recombinant protein (Position: M1-D394) was used as the immunogen for the PSTPIP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PSTPIP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PSTPIP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PSTPIP1

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Autre désignation: PSTPIP1

Sujet: PSTPIP1 antibody detects Proline-serine-threonine phosphatase-interacting protein 1, a cytoskeletal adaptor protein that regulates actin dynamics, immune signaling, and inflammasome activation. PSTPIP1 is primarily expressed in hematopoietic cells, where it interacts with the actin cytoskeleton and tyrosine phosphatases to coordinate immune cell morphology and migration. The PSTPIP1 antibody is extensively used in immunology and inflammation research to study cytoskeletal remodeling and autoinflammatory disease mechanisms.

PSTPIP1 is encoded by the PSTPIP1 gene located on human chromosome 15q24.3. The protein belongs to the F-BAR domain-containing family and features an N-terminal F-BAR domain that mediates membrane curvature and actin binding, along with a C-terminal SH3 domain that interacts with proline-rich regions in partner proteins such as PEST-type tyrosine phosphatases and pyrin. Through these interactions, PSTPIP1 regulates membrane deformation, phagocytosis, and signaling cascades in macrophages and neutrophils.

The PSTPIP1 antibody typically detects a 48-52 kilodalton protein by western blot and produces strong cytoplasmic and membrane-associated staining in immune cells. Functionally, PSTPIP1 links the actin cytoskeleton to signaling complexes, modulating processes such as cell spreading, migration, and inflammasome assembly. Mutations in PSTPIP1 are associated with PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome and other autoinflammatory disorders, where altered protein-protein interactions lead to hyperactivation of the pyrin inflammasome and excessive interleukin-1 beta production.

PSTPIP1 interacts with proteins including WASP, c-Abl kinase, and SHIP1, integrating actin dynamics with immune receptor signaling. In macrophages, it contributes to the formation of podosomes and phagocytic structures. Beyond immune regulation, PSTPIP1 participates in bone remodeling and osteoclast differentiation through cytoskeletal control. NSJ Bioreagents provides a validated PSTPIP1 antibody optimized for western blot, immunoprecipitation, and immunofluorescence applications. This antibody supports research into inflammatory signaling, actin organization, and the molecular mechanisms underlying autoinflammatory diseases.

UniProt: O43586