PAX6 anticorps (AA 1-401)

N° du produit ABIN7869319

Cet anticorps anti-PAX6 Polyclonal Lapin (ABIN7869319) détecte spécifiquement PAX6 dans WB et IF. L’anticorps est réactif avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour PAX6 anticorps (AA 1-401) (ABIN7869319)

Antigène: PAX6 (Paired Box 6 (PAX6))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-PAX6 anticorps

Épitope: AA 1-401

Fonction: Zebrafish Pax6 Antibody / Pax6a / Pax6b

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Pax6 recombinant protein (amino acids M1-M401) was used as the immunogen for the Zebrafish Pax6 antibody. This antibody will detect isoforms a & b.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Pax6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Pax6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: Pax6

Sujet: Paired box protein 6 (Pax6) is a highly conserved transcription factor that plays a central role in the development of the eye, central nervous system, and pancreas. In zebrafish (Danio rerio), Pax6 is encoded by two paralogous genes, pax6a and pax6b, both of which are essential for ocular morphogenesis, neurogenesis, and endocrine cell differentiation.

During embryogenesis, zebrafish Pax6 is expressed in the forebrain, optic vesicles, retina, and spinal cord, where it regulates the expression of genes critical for cell fate determination and tissue patterning. Pax6 is a key regulator of eye field specification and is required for the proper formation of structures such as the lens, retina, and optic tectum. In addition, it contributes to pancreatic islet cell development, particularly in the differentiation of insulin-producing Beta-cells.

Given its evolutionary conservation and well-characterized functions, zebrafish Pax6 is widely used as a model for studying ocular development, neural differentiation, congenital eye disorders (e.g., aniridia), and transcriptional control of organogenesis.

UniProt: P26630

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis