Sphingomyelin Synthase 1 anticorps (AA 1-413)

N° du produit ABIN7869329

Cet anticorps Lapin Polyclonal détecte spécifiquement Sphingomyelin Synthase 1 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Sphingomyelin Synthase 1 anticorps (AA 1-413) (ABIN7869329)

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sphingomyelin Synthase 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Sphingomyelin Synthase 1 anticorps

Épitope: AA 1-413

Fonction: SGMS1 Antibody / Sphingomyelin synthase 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SGMS1 recombinant protein (Position: M1-T413) was used as the immunogen for the SGMS1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SGMS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SGMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Sphingomyelin Synthase 1

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Autre désignation: SGMS1

Sujet: SGMS1 antibody detects Sphingomyelin synthase 1, encoded by the SGMS1 gene. Sphingomyelin synthase 1 is a plasma membrane-associated enzyme that catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. SGMS1 antibody provides researchers with a tool for studying sphingolipid metabolism, membrane biology, and signaling processes linked to cell survival and apoptosis.

Sphingomyelin synthase 1 belongs to the sphingomyelin synthase family of enzymes and is localized at the plasma membrane and Golgi apparatus. Research using SGMS1 antibody has shown that the enzyme regulates levels of sphingomyelin, a major structural component of membranes, while simultaneously producing diacylglycerol, a second messenger that activates protein kinase C. This dual metabolic and signaling role highlights SGMS1 as a central regulator of lipid homeostasis and cell signaling pathways.

Studies with SGMS1 antibody have demonstrated that disruption of SGMS1 alters plasma membrane composition, impairing lipid raft formation and receptor signaling. Deficiency in SGMS1 leads to accumulation of ceramide, which promotes apoptosis, while excess activity favors cell survival and proliferation. This balance underscores the importance of SGMS1 in processes ranging from development to disease.

Dysregulation of Sphingomyelin synthase 1 has been associated with cancer, metabolic disease, and immune dysfunction. Research using SGMS1 antibody has shown that high SGMS1 activity supports tumor cell survival, while inhibition sensitizes cells to apoptosis-inducing agents. In immune biology, SGMS1 influences T cell receptor signaling and cytokine release. These findings make SGMS1 both a biomarker and a potential therapeutic target.

SGMS1 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in cell lines and tissues, immunohistochemistry demonstrates expression in tumors and metabolic tissues, and immunofluorescence highlights subcellular distribution. These approaches make SGMS1 antibody indispensable for lipid biology research.

By supplying validated SGMS1 antibody reagents, NSJ Bioreagents supports studies into sphingolipid metabolism, apoptosis, and disease. Detection of Sphingomyelin synthase 1 provides researchers with insight into how lipid enzymes regulate both membrane composition and signaling.

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin