ODC1 anticorps (AA 1-450)

N° du produit ABIN7869376

Cet anticorps anti-ODC1 Polyclonal Lapin (ABIN7869376) détecte spécifiquement ODC1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ODC1 anticorps (AA 1-450) (ABIN7869376)

Antigène: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ODC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ODC1 anticorps

Épitope: AA 1-450

Fonction: ODC1 Antibody / Ornithine decarboxylase 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human ODC1 recombinant protein (Position: M1-H450) was used as the immunogen for the ODC1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ODC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ODC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ODC1

Antigène: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Autre désignation: ODC1

Sujet: ODC1 antibody detects Ornithine decarboxylase 1, encoded by the ODC1 gene on chromosome 2p25.1. ODC1 antibody is widely used in research on polyamine metabolism, cell growth, and cancer biology. Ornithine decarboxylase 1 is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the decarboxylation of ornithine to produce putrescine. Polyamines are essential for DNA stabilization, transcription, and cell proliferation. Expression of ODC1 is tightly regulated by growth factors, hormones, and oncogenes, with high activity in rapidly dividing cells.

Structurally, ODC1 is a homodimeric enzyme of ~53 kDa per subunit, containing pyridoxal phosphate (PLP)-dependent catalytic sites. The enzyme undergoes rapid turnover regulated by antizyme-mediated degradation, ensuring tight control of polyamine levels. Conserved structural motifs ensure catalytic efficiency across species.

Functionally, ODC1 is critical for cell proliferation and tissue growth. By generating putrescine, it supports synthesis of spermidine and spermine, polyamines required for nucleic acid function and chromatin organization. Overexpression of ODC1 enhances proliferation and tumorigenesis, while inhibition by difluoromethylornithine (DFMO) blocks polyamine synthesis and reduces tumor growth. Researchers use ODC1 antibody to investigate polyamine metabolism, oncogene signaling, and therapeutic interventions.

Clinically, ODC1 overexpression is observed in many cancers, including colon, prostate, and neuroblastoma. It is regulated by oncogenes such as MYC, linking ODC1 to tumorigenesis. Genetic polymorphisms in ODC1 influence cancer risk and response to chemoprevention strategies involving polyamine inhibitors. Beyond oncology, ODC1 has roles in wound healing, immune responses, and neurological function. NSJ Bioreagents supplies ODC1 antibody to support cancer research, metabolism studies, and therapeutic development.

Experimentally, ODC1 antibody is applied in western blotting to detect the ~53 kDa protein, in immunohistochemistry to assess expression in tumors, and in immunofluorescence microscopy to study subcellular distribution. Enzymatic assays combined with ODC1 antibody help correlate expression with catalytic activity.

UniProt: P11926