SV2C anticorps (AA 1-579)

N° du produit ABIN7869485

Cet anticorps Lapin Polyclonal détecte spécifiquement SV2C dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour SV2C anticorps (AA 1-579) (ABIN7869485)

Antigène: SV2C (Synaptic Vesicle Glycoprotein 2C (SV2C))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SV2C est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-SV2C anticorps

Épitope: AA 1-579

Fonction: SV2C Antibody / Synaptic vesicle glycoprotein 2C

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SV2C recombinant protein (Position: M1-A579) was used as the immunogen for the SV2C antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SV2C antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SV2C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SV2C

Antigène: SV2C (Synaptic Vesicle Glycoprotein 2C (SV2C))

Autre désignation: SV2C

Sujet: SV2C antibody detects Synaptic vesicle glycoprotein 2C, encoded by the SV2C gene. Synaptic vesicle glycoprotein 2C is a member of the synaptic vesicle protein family that regulates neurotransmitter release and synaptic transmission. SV2C antibody provides researchers with a critical reagent for studying presynaptic mechanisms, vesicle biology, and neurological disease.

Synaptic vesicle glycoprotein 2C belongs to a family that includes SV2A and SV2B, proteins characterized by multiple transmembrane domains and localization to synaptic vesicles. Research using SV2C antibody has shown that it participates in neurotransmitter loading and exocytosis. SV2C regulates vesicular dynamics by influencing calcium sensitivity and fusion efficiency, ensuring precise control of neurotransmitter release at active zones.

Studies with SV2C antibody have demonstrated that it is expressed primarily in subsets of neurons, including dopaminergic and GABAergic populations. This distribution suggests specialized roles in motor control, reward pathways, and inhibitory signaling. Differences in expression between SV2 isoforms highlight unique contributions of SV2C to synaptic diversity.

Synaptic vesicle glycoprotein 2C has been linked to neurological and psychiatric disorders. Research using SV2C antibody has shown that alterations in SV2C expression are associated with Parkinson disease, where it affects dopaminergic transmission. Variations in SV2C have also been implicated in nicotine addiction and response to antiepileptic drugs. These findings emphasize the clinical relevance of SV2C in nervous system disorders.

SV2C antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression levels in brain tissues, immunohistochemistry reveals localization in discrete neuronal populations, and immunofluorescence demonstrates colocalization with other vesicle proteins. These applications make SV2C antibody a valuable reagent for neuroscience research.

By supplying validated SV2C antibody reagents, NSJ Bioreagents supports studies into synaptic vesicle biology, neurotransmitter regulation, and neurological disease. Detection of Synaptic vesicle glycoprotein 2C provides insights into how specialized presynaptic proteins regulate communication within neural circuits.

UniProt: Q496J9