FER anticorps (AA 1-804)

N° du produit ABIN7869568

Cet anticorps anti-FER Polyclonal Lapin (ABIN7869568) détecte spécifiquement FER dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour FER anticorps (AA 1-804) (ABIN7869568)

Antigène: FER (FER Tyrosine Kinase (FER))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FER est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FER anticorps

Épitope: AA 1-804

Fonction: FER Antibody / FPS/FES-Related tyrosine kinase

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-R804) was used as the immunogen for the FER antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FER antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FER antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur FER

Antigène: FER (FER Tyrosine Kinase (FER))

Autre désignation: FER

Sujet: FER (FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

UniProt: P16591