TFF1 anticorps (AA 1-84)

N° du produit ABIN7869583

Cet anticorps anti-TFF1 Monoclonal Souris (Clone TFF1-7770) (ABIN7869583) détecte spécifiquement TFF1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TFF1 anticorps (AA 1-84) (ABIN7869583)

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFF1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TFF1-7770

Détail du produit anti-TFF1 anticorps

Épitope: AA 1-84

Fonction: Estrogen Inducible Protein pS2 Antibody / TFF1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-84) from the human protein was used as the immunogen for the Estrogen Inducible Protein pS2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Estrogen Inducible Protein pS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Estrogen Inducible Protein pS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TFF1

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Autre désignation: Estrogen Inducible Protein pS2

Sujet: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

UniProt: P04155

Pathways: EGFR Signaling Pathway