Recombinant Parvin, beta anticorps (N-Term)

N° du produit ABIN7869611

Cet anticorps Lapin Monoclonal détecte spécifiquement Parvin, beta dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Parvin, beta anticorps (N-Term) (ABIN7869611)

Antigène: Parvin, beta (PARVB)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Parvin, beta est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: PARVB-8214R

Détail du produit anti-Parvin, beta anticorps

Épitope: AA 1-91, N-Term

Fonction: Beta-Parvin Antibody / PARVB (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: The N-terminal region (residues 1-91) of the human protein was used as the immunogen for the Beta-Parvin antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Beta-Parvin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Beta-Parvin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Parvin, beta

Antigène: Parvin, beta (PARVB)

Autre désignation: Beta-Parvin

Sujet: Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).

UniProt: Q9HBI1