Recombinant CSTA anticorps (AA 1-98)

N° du produit ABIN7869663

L’anticorps anti-CSTA Monoclonal Lapin est utilisé pour la détection de CSTA dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Recombinant CSTA anticorps (AA 1-98) (ABIN7869663)

Antigène: CSTA (Cystatin A (Stefin A) (CSTA))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CSTA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CSTA-9087R

Détail du produit anti-CSTA anticorps

Épitope: AA 1-98

Fonction: Recombinant Cystatin A Antibody / CSTA

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human CSTA protein (within amino acids 1-98) was used as the immunogen for the recombinant Cystatin A antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: 1.Optimal dilution of the recombinant Cystatin A antibody should be determined by the researcher.

2. This recombinant Cystatin A antibody was recombinantly expressed in CHO cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant Cystatin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CSTA

Antigène: CSTA (Cystatin A (Stefin A) (CSTA))

Autre désignation: Cystatin A

Sujet: Cystatin A antibody targets Cystatin A, a cytoplasmic cysteine protease inhibitor encoded by the CSTA gene and a member of the type I cystatin family. Cystatin A is also widely known as Stefin A and functions as an endogenous inhibitor of papain-like cysteine proteases, including cathepsins B, H, and L. By regulating intracellular protease activity, Cystatin A plays an essential role in protecting epithelial cells from excessive proteolysis and maintaining tissue integrity.

Cystatin A is predominantly localized in the cytoplasm and is highly expressed in stratified squamous epithelia such as epidermis, oral mucosa, esophagus, and cervix. It is closely associated with epithelial differentiation and keratinization processes, where controlled protease inhibition is required for proper barrier formation. Cystatin A antibody detection is therefore useful for studying epithelial maturation, protease balance, and barrier-related biology.

Functionally, Cystatin A binds tightly to cysteine proteases and suppresses their enzymatic activity, thereby influencing cellular processes including apoptosis, inflammation, and cell migration. Through modulation of cathepsin activity, Cystatin A contributes to controlled protein turnover and cellular homeostasis. CSTA antibody reagents support research into protease-inhibitor networks that are critical for normal epithelial function and stress responses.

Altered expression of Cystatin A has been reported in multiple disease contexts, particularly in epithelial-derived cancers. Reduced or heterogeneous CSTA expression has been associated with increased invasiveness and poor differentiation, while strong expression is often retained in well-differentiated squamous cell carcinomas. Changes in Cystatin A levels have also been linked to inflammatory skin disorders and barrier dysfunction, highlighting its relevance in both cancer biology and dermatological research.

Clone CSTA/9087R is designed to recognize Cystatin A in research applications. Cystatin A antibody reagents are suitable for detecting protein expression and localization in epithelial tissues and tumor samples, supporting investigations into protease regulation, epithelial differentiation, and disease-associated alterations in cysteine protease inhibition.

UniProt: P01040

Pathways: Response to Water Deprivation