Cet anticorps anti-TFPI2 Monoclonal Souris (Clone TFPI2-13027) (ABIN7869766) détecte spécifiquement TFPI2 dans WB et IHC (p).
L’anticorps est réactif avec des échantillons de Humain.
Optimal dilution of the Tissue factor pathway inhibitor 2 antibody should be determined by the researcher.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Agent conservateur
Azide free
Stock
-20 °C
Stockage commentaire
Aliquot the Tissue factor pathway inhibitor 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Antigène
TFPI2
(Tissue Factor Pathway Inhibitor 2 (TFPI2))
Autre désignation
Tissue factor pathway inhibitor 2
Sujet
The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII with tissue factor, a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Inhibition of Factor VIIa tissue factor activity requires a plasma component (tissue factor pathway inhibitor (TFPI), lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor (EPI)) and factor Xa. TFPI directly inhibits factor Xa, and, in an Xa-dependent fashion, also inhibits the Factor VIIa tissue factor catalytic complex. TFPI is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins VLDL, LDL, and HDL. TFPI-2 (also known as placental protein 5) is a related glycoprotein that was originally isolated from human placenta.