PRAME anticorps (AA 100-250)

N° du produit ABIN7869792

L’anticorps anti-PRAME Monoclonal Souris est utilisé pour la détection de PRAME dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour PRAME anticorps (AA 100-250) (ABIN7869792)

Antigène: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRAME est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: PRAME-9188

Détail du produit anti-PRAME anticorps

Épitope: AA 100-250

Fonction: PRAME Antibody / OIP-4 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant fragment (within amino acids 100-250) of human PRAME protein was used as the immunogen for the PRAME antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the PRAME antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PRAME

Antigène: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Autre désignation: PRAME

Sujet: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

UniProt: P78395

Pathways: Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding