BCOR anticorps (AA 100-400)

N° du produit ABIN7869872

Cet anticorps Souris Monoclonal détecte spécifiquement BCOR dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BCOR anticorps (AA 100-400) (ABIN7869872)

Antigène: BCOR (BCL6 Co-Repressor (BCOR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCOR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BCOR-1311

Détail du produit anti-BCOR anticorps

Épitope: AA 100-400

Fonction: BCOR Antibody / BCL-6 corepressor

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 100-400) from the human protein was used as the immunogen for the BCOR antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the BCOR antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the BCOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur BCOR

Antigène: BCOR (BCL6 Co-Repressor (BCOR))

Autre désignation: BCOR

Sujet: Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin's lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

UniProt: Q6W2J9