Recombinant PRAME anticorps (AA 100-509)

N° du produit ABIN7869879

L’anticorps anti-PRAME Monoclonal Lapin est utilisé pour la détection de PRAME dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant PRAME anticorps (AA 100-509) (ABIN7869879)

Antigène: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PRAME est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PRAME-8558R

Détail du produit anti-PRAME anticorps

Épitope: AA 100-509

Fonction: PRAME Antibody / OIP-4

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 100-509) from the human protein was used as the immunogen for the PRAME antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the PRAME antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PRAME

Antigène: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Autre désignation: PRAME

Sujet: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

UniProt: P78395

Pathways: Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding