LY75/DEC-205 anticorps (AA 1006-1130)

N° du produit ABIN7869885

L’anticorps anti-LY75/DEC-205 Monoclonal Souris est utilisé pour la détection de LY75/DEC-205 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour LY75/DEC-205 anticorps (AA 1006-1130) (ABIN7869885)

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LY75/DEC-205 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CD205-3720

Détail du produit anti-LY75/DEC-205 anticorps

Épitope: AA 1006-1130

Fonction: LY75/DEC-205 Antibody / CD205

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1006-1130 was used as the immunogen for the LY75/DEC-205 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the LY75/DEC-205 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the LY75/DEC-205 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur LY75/DEC-205

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Autre désignation: LY75/DEC-205

Sujet: DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

UniProt: O60449