STRBP anticorps (AA 110-617)

N° du produit ABIN7870104

L’anticorps anti-STRBP Polyclonal Lapin est utilisé pour la détection de STRBP dans des échantillons de Humain, Rat et Souris. Il a été validé pour ELISA, WB, IF, IHC, ICC et FACS.

Aperçu rapide pour STRBP anticorps (AA 110-617) (ABIN7870104)

Antigène: STRBP (Spermatid Perinuclear RNA Binding Protein (STRBP))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRBP est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-STRBP anticorps

Épitope: AA 110-617

Fonction: STRBP Antibody / Spermatid perinuclear RNA-binding protein

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human STRBP recombinant protein (Position: K110-R617) was used as the immunogen for the STRBP antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STRBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur STRBP

Antigène: STRBP (Spermatid Perinuclear RNA Binding Protein (STRBP))

Autre désignation: STRBP

Sujet: The STRBP antibody targets Spermatid perinuclear RNA-binding protein, a multifunctional RNA- and microtubule-associated protein encoded by the STRBP gene. Spermatid perinuclear RNA-binding protein is involved in RNA transport, post-transcriptional regulation, and microtubule organization. It contributes to spermatogenesis, neuronal differentiation, and stress granule assembly. The STRBP antibody provides researchers with a versatile reagent for investigating RNA-binding protein networks and cytoskeletal coordination during differentiation and stress responses.

Spermatid perinuclear RNA-binding protein contains multiple double-stranded RNA-binding motifs (dsRBDs) and a leucine zipper domain that mediate RNA recognition and dimerization. It localizes to the cytoplasm and perinuclear region, where it associates with RNA granules and microtubules. The STRBP antibody supports detection of this localization, enabling studies of its role in mRNA transport and translational control. STRBP is particularly enriched in developing spermatids, where it participates in the storage and regulation of mRNAs required for sperm maturation.

Beyond reproductive function, Spermatid perinuclear RNA-binding protein is expressed in multiple tissues, including brain and heart, where it modulates RNA metabolism and cytoskeletal integrity. It binds to microtubule-associated complexes to stabilize RNA localization during cellular polarization. The STRBP antibody enables visualization of these interactions, providing insight into how STRBP integrates RNA processing with cytoskeletal rearrangement in differentiating cells.

STRBP also plays a role in stress granule formation during cellular stress, interacting with proteins such as Staufen and DDX3X to regulate mRNA triage and translation repression. The STRBP antibody supports studies of these dynamic processes, helping to elucidate the molecular mechanisms underlying mRNA storage and recovery following stress exposure. Dysregulation of STRBP has been linked to infertility, neurodevelopmental disorders, and altered stress responses.

The STRBP antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, producing strong cytoplasmic and perinuclear staining consistent with its RNA granule localization. NSJ Bioreagents provides this antibody as a high-specificity reagent for reliable detection across molecular and cell biology studies. By supporting analysis of Spermatid perinuclear RNA-binding protein expression and function, the STRBP antibody advances understanding of RNA transport, cytoskeletal organization, and gene expression regulation in diverse biological contexts.

UniProt: Q96SI9