Histone H2A anticorps (AA 115-143)

N° du produit ABIN7870200

L’anticorps anti-Histone H2A Monoclonal Souris est utilisé pour la détection de Histone H2A dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Histone H2A anticorps (AA 115-143) (ABIN7870200)

Antigène: Histone H2A

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Histone H2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 938CT5-1-1

Détail du produit anti-Histone H2A anticorps

Épitope: AA 115-143

Fonction: Histone H2AX Antibody / H2AFX

Purification: Protein G affinity

Immunogène: A portion of amino acids 115-143 from the human protein was used as the immunogen for the Histone H2AX antibody.

Isotype: IgG1

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Histone H2AX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Histone H2AX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Histone H2A

Antigène: Histone H2A

Sujet: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

UniProt: P16104