PELI2 anticorps (AA 118-420)

N° du produit ABIN7870263

L’anticorps anti-PELI2 Polyclonal Lapin est utilisé pour la détection de PELI2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IF, FACS et IHC (p).

Aperçu rapide pour PELI2 anticorps (AA 118-420) (ABIN7870263)

Antigène: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PELI2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PELI2 anticorps

Épitope: AA 118-420

Fonction: Pellino 2 Antibody / PELI2

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids D118-D420) was used as the immunogen for the Pellino 2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Pellino 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Pellino 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PELI2

Antigène: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Autre désignation: Pellino 2

Sujet: Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades