MECP2 anticorps (AA 119-453)

N° du produit ABIN7870278

L’anticorps anti-MECP2 Monoclonal Souris est utilisé pour la détection de MECP2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MECP2 anticorps (AA 119-453) (ABIN7870278)

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MECP2 est non-conjugé

Application: Western Blotting (WB)

Clone: 2G3

Détail du produit anti-MECP2 anticorps

Épitope: AA 119-453

Fonction: MECP2 Antibody

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids K119-R453) was used as the immunogen for the MECP2 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the MECP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MECP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MECP2

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Autre désignation: MECP2

Sujet: MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane