HDC anticorps (AA 12-662)

N° du produit ABIN7870302

L’anticorps anti-HDC Polyclonal Lapin est utilisé pour la détection de HDC dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et IHC (p).

Aperçu rapide pour HDC anticorps (AA 12-662) (ABIN7870302)

Antigène: HDC (Histidine Decarboxylase (HDC))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HDC anticorps

Épitope: AA 12-662

Fonction: Histidine decarboxylase Antibody / HDC

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids R12-V662) was used as the immunogen for the Histidine decarboxylase antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Histidine decarboxylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Histidine decarboxylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HDC

Antigène: HDC (Histidine Decarboxylase (HDC))

Autre désignation: Histidine decarboxylase

Sujet: HDC (Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

UniProt: P19113