Utrophin anticorps (AA 1211-2294)

N° du produit ABIN7870323

L’anticorps anti-Utrophin Polyclonal Lapin est utilisé pour la détection de Utrophin dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour Utrophin anticorps (AA 1211-2294) (ABIN7870323)

Antigène: Utrophin (UTRN)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Utrophin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-Utrophin anticorps

Épitope: AA 1211-2294

Fonction: Utrophin Antibody / UTRN

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids L1211-K2294) was used as the immunogen for the Utrophin antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Utrophin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Utrophin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Utrophin

Antigène: Utrophin (UTRN)

Autre désignation: Utrophin

Sujet: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.

UniProt: P46939

Pathways: Skeletal Muscle Fiber Development