MMP20 anticorps (AA 124-405)

N° du produit ABIN7870366

Cet anticorps anti-MMP20 Polyclonal Lapin (ABIN7870366) détecte spécifiquement MMP20 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MMP20 anticorps (AA 124-405) (ABIN7870366)

Antigène: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP20 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MMP20 anticorps

Épitope: AA 124-405

Fonction: MMP20 Antibody / Matrix metalloproteinase 20

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MMP20 recombinant protein (Position: Y124-K405) was used as the immunogen for the MMP20 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MMP20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MMP20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MMP20

Antigène: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Autre désignation: MMP20

Sujet: MMP20 antibody detects Matrix metalloproteinase-20, an extracellular endopeptidase that degrades enamel matrix proteins during tooth development. The UniProt recommended name is Matrix metalloproteinase-20 (MMP20). Also known as enamelysin, this enzyme belongs to the matrix metalloproteinase family responsible for remodeling extracellular matrix components during morphogenesis and tissue repair.

Functionally, MMP20 antibody identifies a 483-amino-acid secreted zinc-dependent protease synthesized as a zymogen that is activated by propeptide cleavage. MMP20 is specifically expressed in ameloblasts and odontoblasts, where it cleaves amelogenin, ameloblastin, and enamelin to enable proper enamel mineralization and organization.

The MMP20 gene is located on chromosome 11q22.2 and exhibits tissue-specific expression limited primarily to developing teeth. Its enzymatic activity contributes to normal enamel formation and maturation during odontogenesis.

Pathologically, mutations in MMP20 cause autosomal recessive amelogenesis imperfecta, a disorder characterized by defective enamel formation and tooth fragility. Altered MMP20 expression has also been implicated in oral cancer and tissue invasion. Research using MMP20 antibody supports studies in dental biology, extracellular matrix remodeling, and developmental biochemistry.

MMP20 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect matrix-degrading enzymes. NSJ Bioreagents provides MMP20 antibody reagents optimized for dental development, tissue remodeling, and protease regulation research.

Structurally, Matrix metalloproteinase-20 features a catalytic zinc-binding domain and a hemopexin-like domain responsible for substrate recognition. This antibody enables investigation of MMP20's function in enamel formation and extracellular matrix turnover.

UniProt: O60882