TOP3B anticorps (AA 128-824)

N° du produit ABIN7870416

L’anticorps anti-TOP3B Polyclonal Lapin est utilisé pour la détection de TOP3B dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC (p).

Aperçu rapide pour TOP3B anticorps (AA 128-824) (ABIN7870416)

Antigène: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOP3B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TOP3B anticorps

Épitope: AA 128-824

Fonction: TOP3B Antibody / DNA topoisomerase 3-beta-1

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids E128-R824) was used as the immunogen for the TOP3B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TOP3B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TOP3B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TOP3B

Antigène: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Autre désignation: TOP3B

Sujet: DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

UniProt: O95985