TTC39B anticorps (AA 129-682)

N° du produit ABIN7870445

Cet anticorps Lapin Polyclonal détecte spécifiquement TTC39B dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TTC39B anticorps (AA 129-682) (ABIN7870445)

Antigène: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTC39B est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-TTC39B anticorps

Épitope: AA 129-682

Fonction: TTC39B Antibody / C9orf52

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids K129-D682) was used as the immunogen for the TTC39B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TTC39B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TTC39B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TTC39B

Antigène: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Autre désignation: TTC39B

Sujet: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.

UniProt: Q5VTQ0