STIL anticorps (AA 13-1287)

N° du produit ABIN7870455

L’anticorps anti-STIL Polyclonal Lapin est utilisé pour la détection de STIL dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC (p) et FACS.

Aperçu rapide pour STIL anticorps (AA 13-1287) (ABIN7870455)

Antigène: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-STIL anticorps

Épitope: AA 13-1287

Fonction: STIL Antibody / SIL / SCL-interrupting locus protein

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids N13-F1287) was used as the immunogen for the STIL antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STIL antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STIL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur STIL

Antigène: STIL (SCL/TAL1 Interrupting Locus (STIL))

Autre désignation: STIL

Sujet: SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene. This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q15468

Pathways: Tube Formation