Erythrocyte Ankyrin anticorps (AA 1300-1844)

N° du produit ABIN7870499

Cet anticorps Souris Monoclonal détecte spécifiquement Erythrocyte Ankyrin dans WB et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Erythrocyte Ankyrin anticorps (AA 1300-1844) (ABIN7870499)

Antigène: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Erythrocyte Ankyrin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 5H2E8

Détail du produit anti-Erythrocyte Ankyrin anticorps

Épitope: AA 1300-1844

Fonction: ANK1 Antibody / Erythrocyte Ankyrin / Ankyrin-1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids N1300-Q1844) was used as the immunogen for the ANK1 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the ANK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ANK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Erythrocyte Ankyrin

Antigène: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Autre désignation: ANK1

Sujet: Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1 gene. Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats, a central region with a highly conserved spectrin binding domain, and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

UniProt: P16157

Pathways: Synaptic Membrane