PCBP2 anticorps (AA 136-276)

N° du produit ABIN7870554

L’anticorps anti-PCBP2 Polyclonal Lapin est utilisé pour la détection de PCBP2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IF et FACS.

Aperçu rapide pour PCBP2 anticorps (AA 136-276) (ABIN7870554)

Antigène: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCBP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-PCBP2 anticorps

Épitope: AA 136-276

Fonction: hnRNP E2 Antibody / Heterogeneous nuclear ribonucleoprotein E2 / PCBP2

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids D136-K276) was used as the immunogen for the hnRNP E2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the hnRNP E2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the hnRNP E2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PCBP2

Antigène: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Autre désignation: hnRNP E2

Sujet: Poly(rC)-binding protein 2, also called Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2), is a protein that in humans is encoded by the PCBP2 gene. The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q15366