Neurogenin 3 anticorps (AA 137-214)

N° du produit ABIN7870569

L’anticorps anti-Neurogenin 3 Polyclonal Lapin est utilisé pour la détection de Neurogenin 3 dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour Neurogenin 3 anticorps (AA 137-214) (ABIN7870569)

Antigène: Neurogenin 3 (NEUROG3)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurogenin 3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Neurogenin 3 anticorps

Épitope: AA 137-214

Fonction: NEUROG3 Antibody / Neurogenin 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NEUROG3 recombinant protein (Position: Q137-L214) was used as the immunogen for the NEUROG3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NEUROG3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NEUROG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Neurogenin 3

Antigène: Neurogenin 3 (NEUROG3)

Autre désignation: NEUROG3

Sujet: NEUROG3 antibody detects Neurogenin-3, encoded by the NEUROG3 gene. Neurogenin-3 is a basic helix-loop-helix transcription factor that plays a central role in the development of endocrine cells in the pancreas and intestine. NEUROG3 antibody provides researchers with a highly specific reagent for studying pancreatic development, endocrine lineage specification, and diabetes biology.

Neurogenin-3 regulates transcriptional networks that guide progenitor cells toward endocrine fates. Research using NEUROG3 antibody has shown that it activates genes required for insulin, glucagon, somatostatin, and pancreatic polypeptide production. In the intestine, it directs progenitors to form enteroendocrine cells, which secrete hormones critical for digestion and energy homeostasis. These findings emphasize its role as a master regulator of endocrine differentiation.

Studies with NEUROG3 antibody have revealed that mutations in NEUROG3 cause neonatal diabetes and congenital malabsorptive diarrhea. These conditions reflect failure of endocrine cell differentiation, leading to severe metabolic and gastrointestinal dysfunction. This demonstrates that Neurogenin-3 is indispensable for human development.

Beyond congenital disorders, research using NEUROG3 antibody has highlighted its role in regenerative biology. Activation of Neurogenin-3 in adult progenitors can stimulate endocrine differentiation, suggesting therapeutic strategies for diabetes through beta-cell regeneration. These findings expand the relevance of NEUROG3 from development to regenerative medicine.

NEUROG3 is also implicated in cancer. Abnormal expression has been detected in gastrointestinal tumors, where it may influence tumor differentiation. Research using NEUROG3 antibody continues to explore how developmental transcription factors become repurposed in oncogenesis.

NEUROG3 antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights endocrine progenitors in pancreatic tissue, western blotting quantifies protein levels in development and disease, and immunofluorescence demonstrates nuclear localization. These applications make NEUROG3 antibody indispensable in developmental biology and disease research.

By supplying validated NEUROG3 antibody reagents, NSJ Bioreagents supports studies into pancreatic and intestinal biology, diabetes, and cancer. Detection of Neurogenin-3 provides researchers with insight into how transcription factors regulate lineage specification and disease.

UniProt: Q9Y4Z2