IPO7 anticorps (AA 142-169)

N° du produit ABIN7870679

Cet anticorps Lapin Polyclonal détecte spécifiquement IPO7 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour IPO7 anticorps (AA 142-169) (ABIN7870679)

Antigène: IPO7 (Importin 7 (IPO7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IPO7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IPO7 anticorps

Épitope: AA 142-169

Fonction: IPO7 Antibody / Importin 7

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 142-169 from the human protein was used as the immunogen for the IPO7 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the IPO7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IPO7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur IPO7

Antigène: IPO7 (Importin 7 (IPO7))

Autre désignation: IPO7

Sujet: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

UniProt: O95373

Pathways: Protein targeting to Nucleus