PATZ1 anticorps (AA 145-680)

N° du produit ABIN7870729

Cet anticorps anti-PATZ1 Polyclonal Lapin (ABIN7870729) détecte spécifiquement PATZ1 dans WB, ELISA, IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PATZ1 anticorps (AA 145-680) (ABIN7870729)

Antigène: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PATZ1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-PATZ1 anticorps

Épitope: AA 145-680

Fonction: PATZ1 Antibody / POZ-, AT hook-, and zinc finger-containing protein 1

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids M145-Q680) was used as the immunogen for the PATZ1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PATZ1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PATZ1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PATZ1

Antigène: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Autre désignation: PATZ1

Sujet: POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

UniProt: Q9HBE1